When we break up, our brains lose their regular supply of these neurotransmitters, and we go into neurological withdrawal. This is how broken hearts break brains. Subjectively, the deficit in these chemicals can make us feel anxious, depressed, and isolated.

What does heartbreak do to your brain?

Recent research has found that people who have recently been through a breakup experience similar brain activity when shown photos of their loved one as they do when in physical pain. Researchers concluded that rejection, and emotional and physical pain, are all processed in the same regions of the brain.

Can heartbreak cause mental illness?

Stressful life events such as a breakup or divorce can sometimes trigger prolonged and severe emotional distress. Experiencing depressive and other symptoms following the end of a relationship is sometimes diagnosed as an adjustment disorder with depressed mood, also sometimes referred to as situational depression.