Pacinian corpuscles sense stimuli due to the deformation of their lamellae, which press on the membrane of the sensory neuron and causes it to bend or stretch.

What stimulates Pacinian corpuscles?

They are rapidly-adapting mechanoreceptors that sense deep, transient (not prolonged) pressure, and high-frequency vibration. Pacinian receptors detect pressure and vibration by being compressed which stimulates their internal dendrites.

What type of sensation activates a Pacinian corpuscle?

In corroboration of this supposition, stimulation of Pacinian corpuscle afferent fibers in humans induces a sensation of vibration or tickle. They make up 10–15% of the cutaneous receptors in the hand. Pacinian corpuscles located in interosseous membranes probably detect vibrations transmitted to the skeleton.