Mast cell stabilizers are medications used to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels.
What drugs are mast cell stabilizers?
Mast cell stabilizer medications include:
- β2-adrenergic agonists.
- Cromoglicic acid.
- Ketotifen.
- Loratadine.
- Desloratadine.
- Methylxanthines.
- Olopatadine.
- Rupatadine.
What is difference between mast cell stabilizers and antihistamines?
Mast cell stabilizers have been proven as effective reducers of allergy signs and symptoms, but in recent years they are rarely used as exclusive single-acting treatment, but rather as dual-treatment with antihistamines, as a result of their slow activation (3–5 days).
