Weight gain was related to the dose of Actos that people took. So if you're taking a higher dose of the medication, you may gain more weight than someone using a lower dose of Actos. An increase in weight can be due to edema, which may be caused by taking Actos. Weight gain can also be the result of gaining body fat.

Does pioglitazone make you gain weight?

Conclusion: Although pioglitazone causes a significant decrease in FBS, HbA1C and triglyceride levels, it is associated with weight gain, which would limit its utility.

Does Actos put weight on you?

Weight gain is a possible side effect of Actos. This was commonly observed in clinical studies of the drug. Researchers noticed that the weight gain was related to the dose of Actos. People who took a higher dose of the drug gained more weight, on average, than people who took a lower dose.