The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. ... The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum.

What is the function of unfolded protein?

The UPR transmits information about protein folding status to the nucleus and cytosol to adjust the protein folding capacity of the cell or, in the event of chronic damage, induce apoptotic cell death.

What causes unfolded protein response?

Multiple perturbations can cause accumulation of unfolded proteins in the endoplasmic reticulum (ER) and activate the unfolded protein response (UPR). These conditions include hypoxia, glucose deprivation, oxidative stress, viral infection, high fat or cholesterol, and mutations in specific proteins.