Dapsone topical is used to treat acne in children, teenagers, and adults. Dapsone is in a class of medications called sulfone antibiotics. It works by slowing or stopping the growth of bacteria and to decrease inflammation.

What is the mechanism of action of dapsone?

As an antimicrobial agent, dapsone is bacteriostatic in action. It inhibits the synthesis of dihydrofolic acid through by competing with para-aminobenzoic acid for the active site of dihydropteroate synthetase [35, 41], thus resembling the action of sulphonamides.

How quickly does dapsone work?

Once the effective dapsone dose is reached, it is effective within days. However, it may take time to reach the effective dose as the medication is started at a low dose and increased slowly over time to avoid side effects.