Prothrombin complex concentrate, also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available.

What is prothrombin complex concentrate used for?

Prothrombin complex concentrates (PCCs) were designed for treatment of bleeding events associated with hemophilia B, congenital deficiencies of the other vitamin K–dependent clotting disorders, or with severe liver disease.

What is prothrombin complex concentrate made from?

Prothrombin complex concentrate (PCC) comes from the process of ion-exchange chromatography from the cryoprecipitate supernatant of large plasma pools and after removal of antithrombin and factor XI.