Research to date shows that CBD is generally safe and has few, if any, minor side effects. But there's one big caveat: CBD does have the potential to interact with some medications. The concern has to do with how the body metabolizes certain substances.

What drugs should not be taken with CBD?

In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly ...

Does CBD interfere with blood pressure medicine?

A 2017 research study found that taking CBD with antihypertensive medications may change the blood concentration of either substance. If an individual uses CBD and blood pressure medications, it is important for them to inform a doctor.