Thyroid dysfunction, manifesting as either overt or subclinical hypothyroidism, negatively affects lipid metabolism: this leads to hypercholesterolemia which progressively increases the risk for cardiovascular disease and, potentially, mortality.

Can hypothyroidism cause high cholesterol?

When you have hypothyroidism, your body doesn't make enough thyroid hormones. This can increase your cholesterol levels. In fact, research suggests that even slightly low levels of thyroid hormones can cause a spike in cholesterol. Thyroid hormones help your liver process blood.

How are hyperlipidemia and hypothyroidism related?

Hypothyroidism is present in 1.4% to 13% of patients with hyperlipidemia. Overt hypothyroidism is a secondary cause of hyperlipidemia and associated coronary heart disease. Cholesterol profiles may be improved by treating overt hypothyroidism.