Burke made his final appearance in the third season, leaving Seattle in the aftermath of his failed wedding. ... While mentioned in passing throughout later seasons, Burke officially returns in the tenth season in order to conclude Cristina Yang's departure from the series.

Does Burke end up paralyzed?

After a life-threatening accident, Burke is brought in to Grey Sloan Memorial Hospital as a patient, and Cristina demands she be the one to perform his intricate surgery. Complications arise and Burke is paralyzed as a result of the operation.

Do Burke and Cristina get back together?

During the first season of Grey's Anatomy, Cristina begins dating Preston Burke (Isaiah Washington). Early on in the season, Burke breaks off the relationship because he does not want it to ruin their reputations. When Cristina has a miscarriage, the two get back together.