If your primary goal is fruit production for human consumption, then mulberry trimming should be done every year to control size and to keep most of the fruit within easy reach. Note that mulberries bloom and fruit on the previous year's growth, so extensive pruning will reduce fruit production.
When should a mulberry tree be trimmed?
Pruning Tips
Pruning should be done when the tree is dormant, usually late winter. Mulberry trees are prone to bleeding. Cuts over 2” in diameter should be avoided because they will most likely not heal.
Why are mulberry trees bad?
because they grow quickly in most soil types and produce a sweet-tart fruit. However, they are messy, rob water from better plants, and are destructive to turf, sidewalks, and driveways. Male mulberry trees produce large amounts of pollen that pose health issues for allergy sufferers.