LTP also occurs at many other synapses, both within the hippocampus and in a variety of other brain regions, including the cortex, amygdala, and cerebellum.

Where does long-term depression occur?

Thus, to make synaptic strengthening useful, other processes must selectively weaken specific sets of synapses. Long-term depression (LTD) is such a process. In the late 1970s, LTD was found to occur at the synapses between the Schaffer collaterals and the CA1 pyramidal cells in the hippocampus.

How does LTP happen?

Long-term potentiation (LTP) is a process in which synapses are strengthened. ... In LTP, after intense stimulation of the presynaptic neuron, the amplitude of the post-synaptic neuron's response increases. The stimulus applied is generally of short duration (less than 1 second) but high frequency (over 100 Hz).