Methoxychlor was first synthesized in 1893 by the reaction of chloral hydrate with anisole in the presence of acetic acid and sulfuric acid. It is produced commercially by the condensation of anisole with chloral in the presence of an acidic condensing agent (IARC 1979; Sittig 1980).

How is methoxychlor made?

Methoxychlor is prepared by the reaction of chloral with anisole (methyl phenyl ether) in the presence of sulfuric acid; the commercial product usually is about 88 percent pure.

Is methoxychlor banned?

It was banned in the U.S. in 2003 due to its toxicity and ability to disrupt endocrine systems. Methoxychlor can behave like the hormone estrogen and profoundly affects the reproductive system.