In prophase, the nucleolus disappears and chromosomes condense and become visible. In prometaphase, kinetochores appear at the centromeres and mitotic spindle microtubules attach to kinetochores. In metaphase, chromosomes are lined up and each
What stage is the kinetochore formed?
During mitosis, each sister chromatid forming the complete chromosome has its own kinetochore. Distinct sister kinetochores can be observed at first at the end of G2 phase in cultured mammalian cells.
Where do kinetochores come from?
Kinetochores form in the central region, or centromere, of a duplicated chromosome. A kinetochore consists of an inner region and an outer region. The inner region is bound to chromosomal DNA. The outer region connects to spindle fibers.
