Most master gardeners agree that the best treatment for Silverleaf Nightshade in residential lawns is to use a non-selective glyphosate product, such as KillzAll Weed and Grass Killer.

How do I get rid of Silverleaf Nightshade?

Hand pulling is the best option to manage Silverleaf Nightshade. Clipping or mowing this weed will only allow it to re-grow. Make sure to include summer cereal into your crop rotation due to the fact that they are tolerant to herbicides that need to be used on Silverleaf Nightshade.

What spray kills nightshade?

Glyphosate works well on nightshade just after fruiting in fall, or in early summer before it flowers but after it leafs out. A setup with an attached sprayer is easy for the average home gardener to use. Spray the herbicide directly on the nightshade leaves until they're wet.