In the bones, most of the free nerve endings

are located in the marrow and the periosteum, where they form a regular network. Anything that damages the structural integrity of a bone, especially a serious injury such as a fracture, will therefore cause pain.

Can human bones feel pain?

Stimulation of specialized pain-sensitive nerve fibers (nociceptors) that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone marrow which relay nociceptive signals to the brain creating the sensation of pain.

Where are nerve endings in bone?

Thus, by 1960, axons and nerve endings had been found in abundance in periosteum, cortex, marrow, and in joint capsules, ligaments, tendons and fascia, especially where these meet the bone. Fetal joints are particularly richly innervated, as are vertebrae and paravertebral structures.