NSAIDs reduce the vasodilation and natriuretic effects of furosemide by inhibiting the synthesis of prostaglandins, resulting in Na⁺ retention, azotemia, and hyperkalemia25). Furosemide induces various electrolyte imbalances including hypokalemia, hypomagnesemia, hypocalcemia, hyponatremia, and hyperuricemia3,16).

Does furosemide cause hyperkalemia or hypokalemia?

As with many diuretics, it can cause dehydration and electrolyte imbalance, including loss of potassium, calcium, sodium, and magnesium. Excessive use of furosemide will most likely lead to a metabolic alkalosis due to hypochloremia and hypokalemia.

How does furosemide affect potassium levels?

Furosemide is mainly used to treat hyperkalemia, which brings about its desired effect by removing the excess serum potassium through its action on loop of Henle. [23] This property of furosemide resulted in an increased urinary potassium levels in experimental rats.