Creatine. Creatine is calorie-free and does not affect insulin response ( 18 ). Pure collagen. This may slightly impair autophagy but shouldn't significantly affect ketosis or fat burning during a fast ( 19 ).

Can I take creatine when fasting?

Some supplements, like creatine, may even be more beneficial when taken with food ( 33 ). Summary Taking dietary supplements during your fasting period is not necessary. However, protein and creatine supplements may support muscle mass. These can be taken during the feeding periods of your intermittent fasting diet.

Can I take creatine on an empty stomach?

Truth: It's true that you should avoid taking creatine on an empty stomach as it can cause cramping, but the notion that you need to take creatine with an insulin spike producing carbohydrate is unfounded.