In her final moments, Signora threatens the Raiden Shogun, calling her and the Traveler "filthy rats," before she is slain by the Shogun's Musou no Hitotachi. Signora disintegrates into ashes. Her death shocked many Fatui, who expressed surprise at her demise.

Did Signora survive?

La Signora died because Traveler challenged her to a duel in front of the shogun, and she accepted, losing meant dying, same thing happened with Kazuha's friend, he fought Sara and lost, so Raiden killed him.

Is Signora going to be playable?

La Signora is one of the Fatui Harbingers. She has been long-rumoured to be an upcoming playable character in the hit gacha game. While she still isn't a playable character, she recently came back as a boss fight in Update 2.1, and you can check our useful guide about it.