Why Do Antipsychotics Make You Gain Weight? Antipsychotic drugs can make you hungrier, so you might eat more. That's because they change the way your brain and hormones work together to control your appetite. You might crave sweets or fatty foods.

Can Abilify cause rapid weight gain?

Abilify is also associated with metabolism problems. This can lead to weight gain and dangerously high blood sugar levels.

Has anyone gained weight on Abilify?

But after about 11 weeks, those who took Zyprexa had gained 18.7 pounds; Seroquel, 13.4 pounds; Risperdal, 11.7 pounds; and Abilify, 9.7 pounds. Their waists typically expanded three inches with Zyprexa, and two inches with the others.