When taken by mouth: CLA is likely safe when taken in amounts normally found in foods, such as milk and beef. It is possibly safe when taken in larger amounts as medicine. It might cause side effects such as stomach upset, diarrhea, nausea, fatigue, and headache.

Does CLA interfere with any medications?

Conjugated linoleic acid might slow blood clotting. Taking conjugated linoleic acid along with medications that also slow clotting might increase the chances of bruising and bleeding.

Does CLA affect menstrual cycle?

It seems that CLA may play an effective role in reducing the ovulation rate in mice as CLA adversely affected female reproduction and it had negative effects on systemic and local hormones involved in ovulation.