EpiPen® or EpiPen Jr® should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries.

Where is the best place to administer epinephrine?

Epinephrine should be injected only in the middle of the outer side of the thigh, and can be injected through clothing if necessary in an emergency.

Why does an EpiPen have to be injected in the thigh?

As opposed to the upper arm, the thigh muscle is one of the body's largest muscles with more blood supply, so it allows much faster absorption of the medication. The outer thigh, versus the front of the thigh, is recommended because it provides a skin area with thinner tissue and less fat. Dr.