These results indicate that more embryos produced by ICSI are aneuploidy as compared with embryos produced by regular IVF. The results indicate that in vitro manipulation of oocytes for ICSI procedure may have adverse effect on human oocytes, and it may be one of the reasons causing aneuploid embryos in human IVF.

Does ICSI increase aneuploidy?

CONCLUSIONS: Embryo aneuploidy rate (per couple) was significantly higher when oocytes were fertilized by ICSI, compared to those that were fertilized by IVF.

Can ICSI cause chromosomal abnormalities?

Findings from some but not all studies suggest that ICSI is associated with an increased risk for chromosomal abnormalities, autism, intellectual disabilities, and birth defects compared with conventional IVF. These increased risks may also be due to the effects of subfertility.