Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at a greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition.

What are the main causes of spondylitis?

The main cause is aging, but the way aging affects your spine can lead to other changes and problems. Spondylosis is a cascade: One anatomical change occurs, which leads to more degeneration and changes in your spine's structures. These changes combine to cause spondylosis and its symptoms.

Can spondylitis be cured?

There's no cure for ankylosing spondylitis (AS), but treatment is available to help relieve the symptoms. Treatment can also help delay or prevent the process of the spine joining up (fusing) and stiffening. In most cases treatment involves a combination of: exercise.