Medial prefrontal cortex (MPFC) is among those brain regions having the highest baseline metabolic activity at rest and one that exhibits decreases from this baseline across a wide variety of goal-directed behaviors in functional imaging studies.

Is the prefrontal cortex in the medial temporal lobe?

The prefrontal cortex is considered to support processes of cognitive control that are important for memory function. ... At encoding, information is processed by a hierarchy of unimodal and polymodal cortical areas, resulting in a bound representation of associated features in the medial temporal lobe.

What activates the medial prefrontal cortex?

Having a positive reputation, which covaries with high social desirable traits, activates the medial prefrontal cortex (mPFC) and striatum [6]. By contrast, a negative reputation activates the mPFC, anterior insula, and anterior cingulate cortex (ACC) [7].