Under normal conditions of fear suppression, the medial prefrontal cortex (mPFC) is activated and inhibits amygdala output (filled arrow). This dominance of the mPFC results in less freezing in response to a conditioned stimulus (CS; i.e., extinction).

Does the prefrontal cortex control the amygdala?

Prefrontal Cortex: ↑ The control center of the brain that controls thoughts and actions. Its main job is to control the emotional responses to stress by regulating the amygdala.

What is the relationship between the prefrontal cortex and the amygdala?

In both species, they find that the amygdalofugal and uncinate pathways converge as they enter the lower PFC, before terminating in different regions of the frontal pole. The connectivity of both pathways was distinct from nearby control pathways. Folloni et al.