The B Cell: B cells mature in the bone marrow or in the lymph node. Bone Marrow: Mature B cells express antibodies on their surface, which are specific for a particular antigen.

Where do B cells arise and mature?

Both B and T lymphocytes originate in the bone marrow but only B lymphocytes mature there; T lymphocytes migrate to the thymus to undergo their maturation. Thus B lymphocytes are so-called because they are bone marrow derived, and T lymphocytes because they are thymus derived.

Where do b1 B cells mature?

B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph.