1. Platelet transfusion is indicated for patients with clinically significant bleeding in whom thrombocytopenia is thought to be a major contributory factor, even if the platelet count is >10x109/L. 2. In patients with critical bleeding requiring massive blood transfusion.

What platelet level requires a blood transfusion?

There is reasonable consensus that for patients who are bleeding, septic, or hemodynamically unstable, the threshold for transfusion should be raised to 15,000-20,000/µL. Patients with life-threatening bleeding in the chest or head are usually transfused at higher platelet count thresholds (30,000-50,000/µL).

At what platelet count would you provide a prophylactic platelet transfusion?

Prophylactic platelet transfusions may be appropriate at 5,000- 10,000/uL to prevent spontaneous bleeding.