Trypsinogen is an inactive precursor produced by the pancreas that is converted to the enzyme trypsin. This test measures the amount of trypsinogen in the blood. Normally, trypsinogen is produced in the pancreas and transported to the small intestine.

How do you test for trypsin?

Trypsin and chymotrypsin will be detectable in the small intestine and in the stool if the pancreas is functioning normally. In people with cystic fibrosis, mucous plugs can block the pancreatic ducts that lead into the small intestines, preventing trypsinogen and chymotrypsinogen from reaching the intestines.

What causes high trypsinogen?

Trypsinogen is a chemical made by the pancreas. It's usually made in small amounts to help with digestion. In premature babies or babies who had a stressful birth, levels of trypsinogen in the blood may be higher than normal. High levels of trypsinogen in a newborn may mean the baby has cystic fibrosis (CF).