Compensatory sweating, which is a major problem in many patients who have undergone transthoracic endoscopic sympathectomy for hyperhidrosis, has only rarely been reported after botulinum toxin. However, this potential side-effect of botulinum toxin treatment has not been systematically examined.

How does Botox affect sweating?

Botox works by blocking the nerves responsible for activating your sweat glands. Normally, your nervous system activates your sweat glands when your body temperature rises. This is how your body automatically cools itself.

Does compensatory sweating go away?

In all patients, compensatory sweating was resolved after interruption of the ganglia or sympathetic nerves related to compen- satory sweating. A decrease in the skin blood perfusion was observed by stimulating sympathetic nerve. Central Message Compensatory sweating is caused by denatured sympathetic nerves.