Potassium-sparing diuretics are often combined with either a loop diuretic

or a thiazide diuretic. This is because they help to keep the right amount of potassium in your blood and they help other diuretics to remove fluid from the body.

What is the mechanism of action of potassium-sparing diuretics?

Mechanism of Action: A potassium-sparing diuretic that inhibits sodium, potassium, ATPase. Interferes with sodium and potassium exchange in distal tubule, cortical collecting tubule, and collecting duct. Increases sodium and decreases potassium excretion. Also increases magnesium, decreases calcium loss.

Why are potassium-sparing diuretics the weakest diuretics?

Potassium-sparing diuretics are medicines that increase diuresis (urination) without the loss of potassium. They are generally weak diuretics and work by interfering with the sodium-potassium exchange in the distal convoluted tubule of the kidneys or as an antagonist at the aldosterone receptor.