If methotrexate is taken too frequently – daily instead of weekly, for instance – it can suppress bone marrow, reducing blood cell production and impairing the immune system. This can make the body susceptible to infections and, in the worst-case scenario, result in death.

Is MTX dangerous?

Methotrexate may cause serious or life-threatening skin reactions. If you experience any of the following symptoms, call your doctor immediately: fever, rash, blisters, or peeling skin. Methotrexate may decrease the activity of your immune system, and you may develop serious infections.

Will methotrexate shorten my life?

Methotrexate My Decrease Rate of Mortality in Rheumatoid Arthritis (RA) Numerous studies have shown that patients with RA have reduced life expectancy.