Two studies conducted in 2017 and 2018 concluded that long-term use of PPIs may increase the risk of stomach cancer, also called gastric cancer.
Is it safe to take PPI long term?
Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.
Does PPI increase risk of gastric cancer?
PPI use significantly increased the risk of gastric cancer [hazard ratio (HR) = 2.44; 95%CI: 1.42-4.20], unlike H2RA (HR = 0.72; 95%CI: 0.48-1.07). Moreover, the positive association between PPI and gastric cancer showed dose- and duration-dependent relationship[29].
