The pain is usually relieved with nitroglycerin. The chest pain with GERD is typically burning and may extend upward. Pain due to GERD usually occurs after meals and is often relieved by antacids.

Can nitroglycerin help esophageal spasms?

Nitroglycerin given under the tongue (sublingual) may help a sudden episode of esophageal spasm. Long-acting nitroglycerin and calcium channel blockers are also used for the problem. Long-term (chronic) cases are sometimes treated with low-dose antidepressants such as trazodone or nortriptyline to reduce symptoms.

Can nitroglycerin cause acid reflux?

These medicines relieve chest pain (angina) because they open up blood vessels that supply the heart. Nitroglycerin is an example. Nitrates are a common cause of heartburn. Like many other drugs that lead to heartburn, they relax the LES.