What is the mechanism of action of Polyenes?

Mechanism of action

Polyenes bind to ergosterol in the cell membrane of fungi and form aqueous pores that promote leakage of intracellular ions and disrupt active transport mechanisms dependent on membrane potential. They can be fungistatic or fungicidal.

How do antifungals work?

Antifungal medicines work by either: killing the fungal cells – for example, by affecting a substance in the cell walls, causing the contents of the fungal cells to leak out and the cells to die. preventing the fungal cells growing and reproducing.