Alloxan is one of the common diabetogenic agents used to assess the anti-diabetic or hypoglycemic potential of both pure compounds and plant extracts in studies involving diabetes.

What is alloxan treatment?

Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species.

How do you induce alloxan in rats?

Anti-diabetic Activity in Alloxan Induced Diabetes Model

Diabetes was induced in 80 male albino rats by injecting 120 mg/kg of Alloxan monohydrate intra-peritoneally dissolved in 0.9% w/v cold normal saline to overnight-fasted rats (12 h).