In Where Nothing Stays Buried, once Klaus has the manpower and the perfect plan to do so, Klaus retaliates against Lucien for killing Cami. Freya Mikaelson is able to extracted the Beast's curse from Lucien's body and Klaus kills Lucien as revenge for killing Cami.

Does Lucien die in Vampire Diaries?

Lucien completes his transition into the first sired vampire Believing that he was now a vampire, Lucien stormed out of the dungeon with the knife and tried to murder Tristan but was stabbed in the back and killed by one of the guards.

Does Lucien's bite have a cure?

Lucien then explains two things to the young witch: 1) The ancestors are helping him because he promised them he'd exterminate the Original family, and 2) His bite has no cure.