ENB increase the work load of your video card. Yes they can cause the game to crash or your whole computer if your video card cant handle the extra work. No need to reinstall the game because of a bad ini file. just delete the ini and start the game via the launcher and a new one at default settings will be added.

What causes random CTD Skyrim?

If you play the Special Edition version of Skyrim, the most common reason your game is crashing is likely the fact Bethesda recently updated it. ... Mods that rely on that version of the game fail to work, resulting in the game crashing due to version incompatibilities.

What are CTD issues?

Short for crash to desktop, CTD is a term referring to program crash phenomena (it normally happens to games), in which the program abruptly terminates without displaying a warning or error message and displays the desktop screen instead.