Their study shows UVB irradiation targets a particular protein in the body called CXCL5 that plays a role in pain sensitivity. Overexposure to the sun causes the protein to be overexpressed and triggers the pain and inflammation associated with sunburn.

How long does it take for a sunburn to stop hurting?

Pain from a sunburn usually starts within 6 hours and peaks around 24 hours. Pain will usually subside after 48 hours. You can reduce pain with over-the-counter pain relievers such as ibuprofen (Motrin, Aleve) or aspirin (Bufferin).

How do you take the sting out of a sunburn?

Pop an aspirin, ibuprofen or another non-steroidal anti-inflammatory medication to ease pain and reduce swelling. A hydrocortisone cream can help take the edge off, too. Slather on moisturizer. Whether your skin is newly burned or already peeling, moisturizer helps promote healing.