Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age‐related white matter hyperintensities: the LADIS Study.

What causes atrophy of corpus callosum?

The major cause of atrophy of the corpus callosum may be axonal degeneration arising from damage to cortical neurons. In addition, severe cytoskeletal abnormality in the cerebral white matter might accentuate the degree of callosal atrophy.

What is parenchymal atrophy?

Parenchymal atrophy was defined as a region where islets of Langerhans remained and were replaced with fat or had surrounding fibrosis. CIS was defined as high-grade PanIN [14], formerly the PanIN-3 category [13].