Although they limit the enzyme's ability, these N-terminal extensions of the enzyme or a “prosegment” often aid in the stabilization and folding of the enzyme they inhibit. The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised.

What is the function of zymogen cells?

function in digestive system

At the base of the gland are the zymogenic (chief) cells, which are thought to produce the enzymes pepsin and rennin. (Pepsin digests proteins, and rennin curdles milk.)

What is the role of Zymogens in blood clotting?

Blood clots are formed by a cascade of zymogen activations: the activated form of one clotting factor catalyzes the activation of the next (Figure 10.37). Thus, very small amounts of the initial factors suffice to trigger the cascade, ensuring a rapid response to trauma.