In the general population, statin use was associated with a three-fold higher rate of osteoporosis than controls (OR: 3.62, 95% CI 3.55 to 3.69, p<0.01).

Do statins make osteoporosis worse?

Cholesterol-lowering statin drugs may have an added benefit, or risk, depending on the dose. New research suggests that a low dose of statins may protect against osteoporosis, but that high doses may increase the risk for the bone-damaging condition.

What medications can increase risk of osteoporosis?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.