What causes pemphigus vulgaris? Pemphigus vulgaris is not fully understood. Experts believe that it's triggered when a person who has a genetic tendency to get this condition comes into contact with an environmental trigger, such as a chemical or a drug.

Where does pemphigus come from?

What causes pemphigus? Pemphigus is an autoimmune disorder. With an autoimmune condition, proteins in your immune system called antibodies attack your body's own cells. The particular autoimmune reaction involved with pemphigus causes blisters.

How does pemphigus start?

Pemphigus vulgaris occurs when the immune system mistakenly makes antibodies against proteins in healthy skin and mucous membranes. The antibodies break down the bonds between the cells, and fluid collects between the layers of the skin. This leads to blisters and erosions on the skin.