NSAIDs, by inhibition of prostaglandins and bradykinin, produce vasoconstriction of the afferent renal arteriole and reduce the ability of the kidney to regulate (increase) glomerular blood flow.

Are NSAIDs vasodilators?

NSAIDs also inhibit the vasodilating effects of prostaglandins and the production of vasoconstricting factors—namely, endothelin-1. These effects can contribute to the induction of hypertension in a normotensive or controlled hypertensive patient.

Do anti inflammatories cause vasoconstriction?

Prohypertensive effects of non-steroidal anti-inflammatory drugs are mostly due to vasoconstriction.