Sulfonamides are prepared by the reaction of a sulfonyl chloride with ammonia or an amine. Certain sulfonamides (sulfadiazine or sulfamethoxazole) are sometimes mixed with the drug trimethoprim, which acts against dihydrofolate reductase.

What is the source of sulfonamides?

It was found that animal husbandry contributed 15.2% of total sulfonamides, while human sources contributed 28.5%, and combined human and mariculture sources contributed 56.3%. In addition, the mariculture contribution was 24.1% of total sulfonamides into the sea based on mass flux estimation.

Is sulfonamide a natural?

(1, 2) Natural products that contain a primary sulfonamide or primary sulfamate group in their structure are known, but they are rare. ... Sulfamates 4–7 were isolated from various terrestrial actinomycetes (Streptomyces species),(6-10) while 3 was discovered in the soil microbe Streptomyces calvus.