Function. By definition, a cofactor is a nonprotein ion or molecule required by the enzyme for its function. If the cofactor is removed, the enzyme will not be able to do its job and will no longer work as a catalyst.

What is an enzyme without a cofactor?

An inactive enzyme without the cofactor is called an apoenzyme, while the complete enzyme with cofactor is called a holoenzyme.

Can enzymes function without coenzymes?

An enzyme without a coenzyme is called an apoenzyme. Without coenzymes or cofactors, enzymes cannot catalyze reactions effectively. In fact, the enzyme may not function at all. ... They attach to a portion of the active site on an enzyme, which enables the catalyzed reaction to occur.