How do potassium-sparing diuretics work? Amiloride and triamterene work by making the kidneys pass out more fluid. They do this by interfering with the transport of salt and water across certain cells in the kidneys. As more fluid is passed out by the kidneys, less fluid remains in the bloodstream.

How do potassium-sparing drugs work?

Potassium-sparing diuretics are medicines that increase diuresis (urination) without the loss of potassium. They are generally weak diuretics and work by interfering with the sodium-potassium exchange in the distal convoluted tubule of the kidneys or as an antagonist at the aldosterone receptor.

How do potassium-sparing diuretics lower blood pressure?

They lower blood pressure by helping your body eliminate sodium and water through your urine. However, some diuretics can also cause you to eliminate more potassium in your urine. This can lead to low potassium levels in your blood (hypokalemia).