melanocyte-stimulating hormone (MSH), also called intermedin or melanotropin, any of several peptides derived from a protein known as proopiomelanocortin (POMC) and secreted primarily by the pituitary gland.

Where is MSH produced?

Melanocyte-stimulating hormone describes a group of hormones produced by the pituitary gland, hypothalamus and skin cells.

How is MSH made?

Melanocytes in skin make and secrete MSH in response to ultraviolet light, where it increases synthesis of melanin. Some neurons in arcuate nucleus of the hypothalamus make and secrete α-MSH in response to leptin; α-MSH is also made and secreted in the anterior lobe of the pituitary gland.