What medications cause weight gain? Antipsychotic drugs, antidepressants , and mood stabilizers are common drugs that have the most potential to increase weight gain. All 12 of the leading antidepressants, including fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro), make gaining weight more likely.

Why did I gain so much weight on Prozac?

When taken for an extended period of time, patients using Prozac were found to gain an amount of weight that was comparable to weight gain in study participants who received a placebo. Therefore, it is likely that this weight gain is due to recovery from depression rather than the medication itself.

Does Prozac make it hard to lose weight?

As an SSRI, Prozac increases the levels of serotonin in the brain and these are generally the first-line treatment for depression. Any weight loss you may experience while taking Prozac may only be temporary and weight gain after the first few months may be possible.