All three have gone blind or have worsened eyesight at some point*. Itachi and Sasuke have also been shown using Amaterasu which makes the eyes bleed afterwards.

What does Amaterasu do to your eye?

Amaterasu produces black flames at the focal point of the user's vision. ... Amaterasu does not ordinarily require hand seals to be performed, though Sasuke Uchiha once used the Tiger hand seal, which is common for fire techniques. This technique can also be sealed within the Sharingan of another person.

Does using the Sharingan cause blindness?

Use of the Mangekyō Sharingan causes blindness over time, but this can be negated by transplanting another pair of Mangekyō Sharingan from a close relative, such as a sibling, to acquire "eternal" Mangekyō that never lose their sight.